Effects of methanol leaf extract of Dryopteris filix-mas on catalase activity and malondialdehyde levels in the brain of adult male Wistar rats

This study was carried out to determine the effect of methanol leaf extract Dryopteris filix-mas on catalase (an antioxidant) activity and malondialdehyde oxidative stress marker) levels in brain wistar rats. Methanol prepared by Soxhlet extraction. Twenty (20) adults male rats were used for this study. The animals grouped into four groups; 1 (normal control); 2 (administered 100mg/kg filix extract) 3 250mg/kg extract); 4 (Administered 500mg/kg extract). so treated after 21 days, sacrificed. harvested prepare tissue homogenates biochemical assay MDA using standard procedures. Results obtained show that varying doses plant caused a dose dependent increase when compared control group. However, increases found be statistically insignificant (p>0.05). Administration slightly decreased level, while increased experimental 21days treatment period these observed changes results shows different did not cause significant damage animals.